Bringing together 10 incubators and business support organizations from BE, NL and DE, the projects aims at supporting the creation of 150 internationally oriented start-up companies till the end of 2019. In order to achieve this aim, the partners propose to launch and implement an “EMR START-UP Program”, designed to offer free working space and individual coaching to “undetected talents with entrepreneurial spirit” from the participating regions. Accompanied by an euregional team of professional coaches, each “starter“ will have to pass different stages of the start-up program (idea – application – pitching – go/no go – working – business plan – new company). In this context, the provision of the proposed incubation services at cross-border level (network of incubators, euregional team of coaches, joint b2b activities) and hence the creation of an “euregional eco-system” for start-ups is presented as an innovative approach to boost the international orientation of young entrepreneurs. Based on the development of a self-sustaining business model (“EMR START-UP 2.0”), the partners strive for the continuation of the proposed cross-border incubation program beyond the closure of EMR START-UP on 31 December 2019.